CYP3A

OBJECTIVE To observe the distribution of CYP3A activity in the healthy school children .

目的观察中国汉族正常儿童体内CYP3A活性的分布。

METHODS The hydrocortisone probe was used to determine the CYP3A activity .

方法用氢化可的松探针测定健康儿童个体内CYP3A酶活性。

For patients taking moderate CYP3A inhibitors , ranolazine dosing should be limited to500 mg twice daily .

患者在服用中度CYP3A抑制剂时，雷诺嗪剂量应限制在500mg内，每天两次。

CONCLUSION : Furanocoumarin composition can be an index to predict citrus fruit juice-drug interaction based on CYP3A inhibition ;

结论：根据呋喃香豆素组成可以预测柑橘类果汁因为抑制CYP3A引起的药物相互作用；

Objectives To study the effects of cyclosporin A ( CsA ) and coadministration of methylprednisolone ( MP ) on the activities of human cytochrome P450 3A ( CYP3A ) .

目的探讨甲基强的松龙（MP）与环孢素A（CsA）合用时对肝脏CYP3A活性的影响。

Objective : To study the effect of Lycium Barbarum Polysaccharide ( LBP ) on the activity and gene expression of hepatocyte cytochrome P4503A ( CYP3A ) in rat model with alcoholic fatty liver ( AFL ) .

目的：通过观察枸杞多糖（LBP）对酒精性脂肪肝（AFL）大鼠肝细胞色素P4503A基因和活性的影响，揭示其部分治疗机制。

The expression of cytochrome P450 3A ( CYP3A ) subfamily implicated in drug metabolism in human fetal adrenals and livers was detected by using enzyme assays and the reverse transcription polymerase chain reaction ( RT PCR ) .

采用酶学和逆转录聚合酶链式反应（RT-PCR）技术，研究与药物代谢密切相关的细胞色素P4503A（CYP3A）在胎肾上腺和胎肝中的表达。