ADPKD

Nowadays there is no effective treatment to protect against progression of ADPKD .

目前尚无有效的治疗方法能控制ADPKD的发生与发展。

Studies of proliferation and apoptosis in ADPKD cyst - lining epithelial cells

多囊肾病囊肿衬里上皮细胞增生与凋亡的研究

Lining the corruption establishment and identification of ADPKD cyst - lining epithelial cell lines

给腐败排个座次多囊肾病囊肿衬里上皮细胞细胞系的建立与鉴定

Conclusions ADPKD cyst - lining epithelial cells synthesize and secret HGF .

结论ADPKD囊肿衬里上皮细胞可合成和分泌HGF。

The search for mutations is one of the most important steps in understanding the molecular mechanisms underlying ADPKD .

因此，检测PKD1基因的突变是理解多囊肾病分子发病机制的重要步骤。

Conclusion : Both proliferation and apoptosis process in cyst lining epithelial cells were dis regulated in ADPKD .

结论：多囊肾病中囊肿衬里上皮细胞的增生和凋亡失调，调节这些过程的基因异常表达介导了多囊肾病囊肿形成。

The above findings suggested that KGF may contribute to the formation and development of renal cyst in ADPKD .

这些结果充分表明了两株细胞存在极大的生物学差异，提示KGF在ADPKD囊肿形成和发展中具有明显的作用。

Effects of a Novel PPAR γ Agonist on Cell Proliferation in ADPKD Cystic-lining Epithelial Cells

新型PPARγ激动剂DH9抑制多囊肾囊肿衬里上皮细胞增殖的作用和机制研究

Objective To study the expression of extracellular matrix and polycystin-1 in ADPKD and their relation to cyst formation .

目的研究常染色体显性遗传型多囊肾病肾组织中细胞外基质和多囊蛋白-1的表达及与囊肿发生的关系。

However , at present the unclearness of pathogenesis and pathophysiology of ADPKD results in no effective treatment to this disease .

但是目前对于该病发病机制及病理生理尚不明了，从而导致治疗方面也无重大突破。

Antiproliferative effect of HMG CoA reductase inhibitor on ADPKD cyst-lining epithelial cell and its mechanism

羟甲基戊二酰辅酶A还原酶抑制剂对多囊肾病囊肿衬里上皮细胞增殖抑制及其机制的研究

Objective To explore the relationship of intracranial aneurysm ( ICA ) and autosomal dominant polycystic kidney disease ( ADPKD ) .

目的探讨颅内动脉瘤（ICA）与多囊肝肾病即常染色体显性遗传性多囊肾病（ADPKD）的关系。

Methods The concentration of SPARC in plasma , urine and cystic fluid from patients with ADPKD and healthy individuals was measured with ELISA .

方法采用ELISA法测定ADPKD患者血浆、尿液、囊肿液以及正常人血浆、尿液中的SPARC浓度；

Methods : we collected the ADPKD kidney tissues and normal kidney tissues samples , extracted the total proteins and enriched the phosphoproteins .

方法：收集多囊肾病肾组织与正常肾组织，提取总蛋白，进行磷酸化蛋白质的富集。

GGPP was able to reverse the growth inhibition of lovastatin in ADPKD cyst-lining epithelial cells and fibroblasts .

GGPP能明显逆转洛伐他汀对ADPKD囊肿衬里上皮细胞和间质成纤维细胞I型和W型胶原分泌的抑制作用（尸<0.01）。

CONCLUSION An ADPKD cyst lining epithelial cell line has been established and identified , which can be used in the research of ADPKD cellular and molecular mechanism .

结论：经鉴定，ADPKD囊肿衬里上皮细胞系已建立，可用于ADPKD细胞及分子生物学的研究。

Objective : Cyst lining epithelial cell proliferation and apoptosis are implicated in the pathogenesis of cyst formation in autosomal dominant polycystic kidney disease ( ADPKD ) .

目的：研究多囊肾病囊肿衬里上皮的增生与凋亡及相关蛋白表达。

The quantitative information of EGF in the culture medium of cyst-lining epithelia cells and bodyfluids of ADPKD rats and patients were assayed by ELISA .

ELISA检测囊肿衬里上皮细胞培养上清、多囊肾病大鼠和患者体液中EGF含量。

Infectious complications with the exception of urinary tract infections ( UTIs : ADPKD 43.4 % , vs. 10.9 % ) were diagnosed in similar frequency in the graft recipients .

除尿路感染（尿路感染：ADPKD43.4%；对照组10.9%）以外的感染发生率相似。

Objective : To study the differential gene expression pattern between autosomal dominant polycystic and normal kidney tissue , and to deduce the etiological factor and treatment for autosomal dominant polycystic kidney disease ( ADPKD ) .

目的：应用表达谱芯片研究常染色体显性遗传多囊肾病（ADPKD）与正常肾组织基因表达的差异，探讨此病的致病因素及可能的治疗途径。

Objective To investigate the effect of recombinant human hepatocyte growth factor ( rhHGF ) on the proliferation of autosomal dominant polycystic kidney disease ( ADPKD ) cyst lining epithelial cells and its signal transduction mechanism .

目的研究重组人肝细胞生长因子（rhHGF）对常染色体显性多囊肾病（ADPKD）囊肿衬里上皮细胞增殖的影响及其信号转导途径。

Objective To investigate the concentration of secreted protein acidic and rich in cysteine ( SPARC ) in body fluid of patients with autosomal dominant polycystic kidney disease ( ADPKD ) and the origin of its secretion .

目的研究富含半胱氨酸的酸性分泌糖蛋白（SPARC）在常染色体显性多囊肾病（ADPKD）患者体液中的浓度及其分泌来源。

The hypertension symptom relief rate was 70 % , 65 % , 59 % and 50 % at 3,5,12 and 24 months , respectively . Conclusion : For ADPKD patients with debilitating pain , extensive LCD can provide durable relief .

高血压症状的缓解率术后3个月、6个月、12个月、24个月分别为70%、65%、59%、50%。

In addition , the correlation of apoptotic cell number and sectional area ratio with the status of renal function was analyzed respectively . Results Apoptotic DNA fragments were detected in all polycystic kidney tissues from patients with or without renal failure and cultured ADPKD cyst-lining epithelial cells .

结果无或有肾功能衰竭的ADPKD肾组织中肾小球、肾小管上皮和囊肿衬里上皮细胞、体外培养的ADPKD囊肿衬里上皮细胞均发生凋亡。

Objective : To study the effects of recombinant human hepatocyte growth factor ( rhHGF ) on the synthesis of extracellular matrix ( ECM ) and matrix metalloproteinases and tissue inhibitor of metalloproteinases in autosomal dominant polycystic kidney disease ( ADPKD ) cyst lining epithelial cells .

目的：观察重组人肝细胞生长因子（rhHGF）对常染色体显性遗传性多囊肾病（ADPKD）囊肿衬里上皮细胞合成细胞外基质（ECM）、基质金属蛋白酶及其抑制剂的作用。

Objective : To investigate the effect of keratinocyte growth factor ( KGF ) on the cell cycle and regulatory protein of cyst-lining epithelia in autosomal dominant polycystic kidney disease ( ADPKD ) and explore the role of KGF in the ADPKD pathogenesis and development .

目的：研究角质细胞生长因子（KGF）对常染色体显性多囊肾病（ADPKD）囊肿衬里上皮细胞细胞周期及其调控蛋白的影响，以初步探讨ADPKD囊肿发生、发展的细胞学机制。