华蟾毒精
- 网络cinobufagin;cinobufaginol;Cinobufotalin
华蟾毒精
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目的了解中药成分华蟾毒精(cinobufagin,CBG)的体外抗癌活性及其主要作用机制。
AIM To explore anticancer activity and mechanism of Cinobufagin ( CBG ) in vitro .
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华蟾毒精抗癌作用的体外研究
Experimental study on anticancer action of cinobufagin in vitro
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方法:采用体外人肠内细菌粗酶与华蟾毒精和羟基华蟾毒精温孵法;
Methods : The cinobufagin and cinobufotalin were incubated with crude enzymes of human intestinal bacteria in vitro .
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就抗肿瘤活性而言,华蟾毒精在人及常用实验动物(猴、狗、猪、大鼠、小鼠)中因代谢而失活。
The anticancer activities of cinobufagin would be reduced by the metabolism no matter in human or in monkey , dog , pig , rat and mouse .